饶子和 教授  
Prof. Zihe Rao  
   
 
 
 
 
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简介：
饶子和, 中科院生物物理所所长，“IBP-南开-清华”结构生物学联合研究组组长；2006年5月被任命为南开大学校长。
 
主要科研领域与方向：
重要病毒与肿瘤蛋白质功能、结构与创新药物研究
 
获奖情况：
  • 1999年获“求是杰出青年学者奖”
  • 2000年获国家教育部“长江学者奖励计划”特聘教授
  • 2003年度“何梁何利基金科学与技术进步奖”
  • 2004年被评为国家重点基础研究发展计划（973计划）先进个人
  • 2006年荣获“陈嘉庚生命科学奖”
 
代表性论文:
  1. Sun F, Huo X, Zhai YJ, Wang AJ, Xu JX, Su D, Bartlam M & Rao Z*. 2005. Crystal Structure of Mitochondrial Respiratory Membrane Protein Comples Ⅱ. Cell, 121: 1043-1057

  2. Yang H, Xie WQ, Xue XY, Yang KL, Ma J, Liang WX, Zhao Q, Zhou Z, Pei DQ, J. Ziebuhr, R. Hilgenfeld, K. Y. Yuen, Wong L., Gao GX, Chen SJ, Chen Z, Ma DW, Bartlam M & Rao Z*. 2005. Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases. PLoS Biology, 3(10):e324, 1742-1752

  3. Zhai Y, Sun F, Li X, Pang H, Bartlam M & Rao Z*. 2005. Structural insights into coronavirus transcription/replication from the crystal structure of the SARS-CoV hexadecameric nsp7?nsp8 super-complex. Nature Structural & Molecular Biology, 12(11): 980-986

  4. Wu B, Li P, Liu Y, Lou Z, Ding Y, Shu C, Ye S, Bartlam M, Shen B & Rao Z*. 2004. 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex. Proc Natl Acad Sci USA., 101(22):8348-8353

  5. Bartlam M, Wang G, Yang H, Gao R, Zhao X, Xie G, Cao S, Feng Y & Rao Z*. 2004. Crystal Structure of an Acylpeptide Hydrolase/Esterase from Aeropyrum pernix K1. Structure, 12(8):1481-1488

  6. Xu Y, Liu Y, Lou Z, Qin L, Bai Z, Pang H, Tien P, Gao G* & Rao Z*. 2004. Structural basis for coronavirus-mediated membrane fusion: Crystal structure of mouse hepatitis virus spike protein fusion core. J Biol Chem., 279 (29): 30514-30522

  7. Xu Y, Lou Z, Liu Y, Pang H, Tien P, Gao G.F & Rao Z*. 2004. Crystal structure of Severe Acute Respiratory Syndrome Coronavirus Spike Protein Fusion Core*. J Biol Chem., 279(47): 49414-49419

  8. Yang H, Yang M, Ding Y, Liu Y, Lou Z, Sun L, Zhou Z, Ye S, Pang H, Gao G, Anand K, Bartlam M, Hilgenfeld R & Rao Z*. 2003. The Crystal Structures of SARS Virus Main Protease Mpro and Its Complex with an Inhibitor. Proc Natl Acad Sci USA., 100(23): 13190-13195

  9. Ding Y, Xu G, Yang M, Yao M, George F. Gao, Wang L, Zhang W & Rao Z*. 2003. Crystal structure of the ectodomain of human FcalphaRI. J Biol Chem., 278 (30): 27966-27970 (cover)

  10. Ding Y, Xu M, I Ghosh, Chen Xi, S. Ferrandon, G. Lesage & Rao Z*. 2003. Crystal structure of a mini-intein reveals a conserved catalytic module involved in side chain cyclization of asparagine during protein splicing. J Biol Chem., 278(40): 39133 - 39142

  11. Rao Z, Belyaev A, Fry E, Jones I, Roy P＆Stuart D. 1995. Crystal Structure of SIV Matrix Antigen and its Implications for Virus Assembly. Nature，378(6558): 743-747

  12. Rao Z, Handford P, Mayhew M, Knott V, Brownlee G＆Stuart D. 1995. The Structure of a Calcium Binding Epidermal Growth Factor-like Domain - its Role in Protein-Protein Interactions. Cell, 82(1): 131-141