| 简历: |
- 1992年毕业于中科院兰州化学物理研究所并获得分析化学博士学位。
- 1992-1995年在日本环境厅国立环境研究所从事博士后研究。
- 1995-2000年北京新技术应用研究所副研究员,北京天然产物分离纯化技术研究中心副主任。
- 2000-2004年,美国国家卫生研究院(NIH),国立心、肺和血液研究所(NHLBI)访问学者。
- 2004年6月至今,中国科学院生物物理所研究员。质谱首席科学家。美国质谱学会会员,国际生物大分子质谱(Biomacromolecular
Mass Spectrometry)杂志编委。
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| 研究组工作摘要: |
研究方向:蛋白质组学新技术新方法研究与应用。
- 生物质谱技术在多肽、蛋白质等生物大分子分析鉴定中的应用研究。
- 现代分离技术在多肽、蛋白质等生物大分子分离中的应用研究。
- 亚细胞器蛋白质组学和膜蛋白质组学研究。
- 高通量蛋白质翻译后修饰(如蛋白质磷酸化和蛋白质糖基化等)分析技术研究与应用。
- 定量蛋白质组学技术研究与应用。
- 疾病蛋白质组学研究。
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| 代表性论文: |
- Davis D., Singer K. E., Sierra, M. Narazaki M.,
Yang F. Q., Fales H. M., Yarchoan R. and Tosato
G., Identification of Carboxypeptidase N as an Enzyme Responsible
for C-Terminal Cleavage of Stromal Cell-Derived Factor-1a in the
Circulation. Blood,105(12),4561-4568
(2005).
- Sierra M.1, Yang F. Q.1(as
the first co-author), Narazaki M., Salvucci O., Davis D., Yarchoan
R., Farber J., Zhang H., Fales H. M., and Tosato G. Differential
processing of stromal-derived factor-1 Alpha and Beta explains
functional diversity. Blood, 103 (7)
2452-2459 (2004).
- Yang F. Q. and Ito Y. On-line
flow-injection dectection system and its application to the measurement
of ethanol transfer and osmosiss rate in centrifugal precipitation
chromatography. J. Liq. Chroma. Rel. Tech.,
27, 2979-2085 (2004).
- Ito Y., Yang F. Q., Fitze P.
E., and Sullivan J. V. Improved column design for HSCCC. J.
Chromatogr. A. 1017, 71-81(2003).
- Yang F. Q. and Ito Y., Separation
of alkaloids by CCC (Review), The Encyclopedia of
Chromatogrphy (online) Marcel Dekker, pp1-5(2003).
- Yang F. Q. and Ito Y. A novel
method for the fractionation of dextran by centrifugal precipitation
chromatography, Anal. Chem., 74, 440-445(2002).
- Yang F. Q. and Ito Y. Preparative
separation of lappaconitine, ranaconitine, N-deacetyllappaconitine
and N-deacetylranaconitine from crude alkaloids of sample Aconitum
sinomontanum Nakai by HSCCC. J. Chromatogr. A.
943, 219-225(2002).
- Yang F. Q., Ma Y. and Ito Y.
Separation and purification of isoflavones from a crude extract
from soybean by HSCCC. J. Chromatogr. A.
928, 163-170 (2001).
- Yang F. Q. and Ito Y. pH-Zone-refining
CCC of Lappaconitine from Aconitum sinomontanum Nakai: I. Separation
of prepurified extract", J. Chromatogr. A.
923, 281-285 (2001).
- Yang F. Q., Zhang T. Y. and
Ito Y. Preparative isolation and purification of notopterol and
isoimperatorin from Chinese traditional medicine Notopterygium
forbessi Boiss (Qianghuo in Chinese) by HSCCC". J.
Chromatogr. A. 883 (2000) 67-73.
- Yang F. Q., Zhang T. Y. and
Ito Y. Preparative isolation and purification of hydroxyanthraquinones
from Rheum officinale Baill by HSCCC using pH-modulated stepwise
elution. J. Chromatogr. A. 858, 103-107(1999).
- Yang F. Q. Quan J. Zhang T.
Y. and Ito Y. Preparative separation of alkaloids from the root
of Sophora flavescens Ait by pH-zone-refining CCC. J.
Chromatogr., A., 822, 316-320 (1998).
- Yang F. Q., Zhang T. Y. and
Ito Y. Multidimensional countercurrent chromatography and is applications.
J. Chromatogr. A., 803, 298-301 (1998).
- Edmonds J. S., Shibata Y., Yang F. Q.
and Morita M. Isolation and synthesis of 1-Deoxy-1-dimethylarsinoylribitol-5-sulfate,
a natural constituent of Chondria crassicaulis and other red algae,
Tetrahedron Letters, 38 (33), 5819
(1997).
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