系统生物学研究中心成立于2003年，是生物物理研究所率先在国内组建的专门研究系统生物学的机构。系统生物学是沟通我所结构与分子生物学和脑与认知科学两大传统学科的桥梁，系统生物学中心的建立使生物物理研究所形成了面向未来发展的、有内在紧密联系的三大研究中心布局。

系统生物学作为一门崭新的生物学分支，是以整体性研究为特征的一种大科学，是在细胞、组织、器官和生物体整体水平研究结构和功能各异的各种分子及其相互作用，并通过计算生物学来定量描述和预测生物功能、表型和行为。系统生物学在破译生命密码、预测医学、预防医学和个性化医学的广泛应用，充分显示了其在新药研发、疾病防治、优良种质资源培育等方面的广阔前景，在世界各国越来越受到高度重视。针对生命科学的发展趋势，生物物理研究所及时确立了发展系统生物学的战略部署，组建了系统生物学研究中心，显示其勃勃生机和巨大的发展潜力。

系统生物学研究中心现有院士1人，第三世界科学院院士1人，研究员20人，副研究员1人。中国科学院“百人计划”5人，国家教育部“长江学者特聘教授”2人，国家“杰出青年基金”获得者1人。中心下设13个研究课题组，在读博士生50人，硕士生39人。陆续承担了国家“973”项目、“863”项目、国家自然科学基金、创新工程重大项目、国家科技攻关项目以及中国科学院知识创新工程重大项目等多项重大科研项目。中心有多位科学家在国外大学、研究机构和国际学术组织中任职，每年有科研人员到国外研究机构进行合作研究、讲学和参加学术会议。

目前系统中心的主要研究方向有（1）系统生物学的方法学研究：主要研发适合于系统生物学研究需求的大容量、高通量研究方法和技术，如高通量的细胞和细胞器分选、蛋白质相互作用关系和动力学特性研究等；（2）模式生物系统研究：主要选择合适的模式生物，如果蝇、小鼠等，研究其中诸如内分泌、免疫和神经等模式生物系统的全部系统构成成分和动力学特性，描述系统的输入和输出信息流程，揭示其系统的设计和调控规律；（3）生物信息学研究：发展和完善适合于描述和模拟复杂生物系统的软件系统，研究复杂生物系统的算法和数学模型，收集、整合、维护海量级增长的实验数据，复杂生物系统的动态仿真等；（4）功能结构基因组学研究：以感染与免疫为切入点，系统地测定一批重要蛋白质、蛋白质符合物、蛋白质复杂体系的三维结构，深入研究其功能；（5）膜蛋白质组学研究：生物膜动态变化相关膜蛋白质组学研究，疾病相关膜蛋白质组学研究。

21世纪是系统生物学的时代，生物物理研究所系统生物学研究中心将通过多学科交叉融合的创新性研究，成为我国系统生物学领域科学研究和人才培养的核心基地。系统生物学研究中心正以海纳百川的胸襟，广纳人才；以国际化的标准，苦炼内功；以积极的姿态，参与国内外竞争。热忱欢迎海内外人士来我中心交流与合作，为系统生物学的蓬勃发展贡献力量。

代表性文章

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